Irina Seleznyova-Horner was born in Kiev, Ukraine. Graduated from the Academy of Theatre, Music and Cinema in St. Petersburg. Few years after graduation she became one of the leading actresses at renowned Maly Drama Theatre led by Lev Dodin, where she played Masha in Three Sisters, Alexandra in Brothers and Sisters and Loran in Stars on the morning sky.

In 1990 she immigrated to Israel and became the first Russian speaking actress to break into Israeli theatre scene performing in Hebrew. She worked in one of the most prominent theatres in Israel, The Cameri Theatre and played many roles. Most notable credits include Nina in The Seagull, Titania in The Summer’s night dream, Lady Anna in Richard III, Alma Maller in Alma.  

Together with having extensive career in theatre, Irina has played multiple roles in Russian, Belarussian and Israeli Films and TV productions. Notable credits include lead roles of Liza Pozdnyshev in The Kreutzer Sonata ( dir.M Sheitzer) , Luchiana Farinni  in Moscow vacation (dir.A.Surikova), Larisa in Games of imagination (dir.M Ptashuk), Dvora Ben Iehuda  in The man, who loves Hebrew (dir.Eli Cohen), Tanya in Buskila Twins, Journalist in The work of his life and Sonia in Zinzana.  She also was a host in Israeli  version of TV show Who's line it is anyway.

In 2000 she married a British citizen and moved to the UK, whilst also continuing to work in TV series in Russia including the role of Irina Serebriakova in Era of Sagittarius (2 seasons 24 episodes), and the role of Svetlana Drobysh in Milk and blood - (12 episodes). In theatre she most recently played the role of Dimentzia Petrovna (Mother Russia) in To see Salisbury  at RADA Festival 2019 in London.